The Cytoplasm of Hepatocytes During Carcinogenesis: Electron- And Lightmicroscopical Investigations of the Nitrosomorpholine-Intoxicated Rat Liver P. Bannasch

ISBN: 9783642884016

Published: March 21st 2012

Paperback

122 pages


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The Cytoplasm of Hepatocytes During Carcinogenesis: Electron- And Lightmicroscopical Investigations of the Nitrosomorpholine-Intoxicated Rat Liver  by  P. Bannasch

The Cytoplasm of Hepatocytes During Carcinogenesis: Electron- And Lightmicroscopical Investigations of the Nitrosomorpholine-Intoxicated Rat Liver by P. Bannasch
March 21st 2012 | Paperback | PDF, EPUB, FB2, DjVu, talking book, mp3, RTF | 122 pages | ISBN: 9783642884016 | 5.35 Mb

The transformation of a normal cell into a cancer cell is not a sudden but a slow continuous process which may take years. A systematic study of the morphological and structural changes that take place during this cellular transformation has onlyMoreThe transformation of a normal cell into a cancer cell is not a sudden but a slow continuous process which may take years.

A systematic study of the morphological and structural changes that take place during this cellular transformation has only become possible since methods were developed to induce a high incidence of tumors in experimental animals. The growth of such tumors can be followed during all stages of their development.

For several reasons, rat liver has proved to be particularly suitable. For more than thirty years it has been known that one can induce tumors in rat liver experimentally with many different substances. The azo dyes which were used originally (YOSHIDA, 1932- KINOSITA, 1937) have since been replaced by more potent carcinogens. The recently discovered nitrosamines, dimethylnitrosamine (MAGEE and BARNES, 1956), diethylnitrosamine (SCHMAHL et aI., 1960) and N-nitrosomorpholine (DRUCKREY et aI., 1961) should be mentioned in this context.

Used in the proper dose, these carcinogens lead within a few months to the formation of multicentric hepatomas in practically 100 Ufo of the experimental animals, and are therefore a very useful tool for studies of the cytogenesis of cancer (see BUCHNER, 1961- GRUND MANN, 1961- GRUNDMANN and SIEBURG, 1962- OEHLERT and HARTJE, 1963- BAN NASCH and MULLER, 1964).

The liver parenchyma as such offers a very big technical advantage because it consists of a rather homogenous cell population.



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